COMPOSITION: Doxorif 200 Tablet: Each tablet contains Doxofylline INN 200 mg. Doxorif 400 Tablet: Each tablet contains Doxofylline INN 400 mg. Doxorif Syrup: Each 5 ml syrup contains Doxofylline INN 100 mg. PHARMACOLOGY: Doxorif (Doxofylline) is a noble bronchodilator. It structurally differs from Theophylline due to the presence of a dioxolane group in position 7. Doxofylline selectively inhibits phosphodiesterase-4 thereby relaxes bronchial smooth muscle. However, differently from Theophylline, Doxofylline appears to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the drug. Doxofylline is reported to inhibit platelet activating factor (PAF) and generation of leukotriene production. INDICATIONS: Doxorif (Doxofylline) is used to treat asthma, COPD and bronchospasm. DOSAGE AND ADMINISTRATION: Adults: 1 tablet daily in the evening. On the basis of clinical response the dose may be increased to 1 tablet twice daily. Children (above 6 years of age): 6 mg/kg body weight twice daily. i.e. if body weight is 10 kg, 3 ml (60mg) twice daily.