COMPOSITION Pednil 5 mg Tablet: Each tablet contains Prednisolone BP 5 mg. Pednil 10 mg Tablet: Each tablet contains Prednisolone BP 10 mg. Pednil Oral Solution: Each 5 ml solution contains Prednisolone 5 mg as Prednisolone Sodium Phosphate BP. PHARMACOLOGY Prednisolone is rapidly and well absorbed from the GI tract following oral administration. Prednisolone is 70 – 90% protein bound in the plasma and it is eliminated from the plasma with a half life of 2 to 4 hours. It is metabolized mainly in the liver and excreted in the urine. MODE OF ACTION Prednisolone is a synthetic adrenocortical drug with predominantly glucocorticoid properties. Prednisolone directly inhibits the action of Phospholipase A2 enzyme which is responsible for the production of different inflammatory mediators like Leukotrienes, SRS – A, Prostaglandins etc. INDICATION 1.Endocrine Disorders: Primary or secondary adrenocortical insufficiency congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. 2.Rheumatic Disorders: Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Ankylosing Spondylitis and Subacute Bursitis Osteoarthritis, Psoriatic Arthritis etc. 3.Dermatologic Diseases: Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens - Johnson syndrome). 4.Respiratory Diseases: Symptomatic sarcoidosis, Berylliosis, Aspiration Pneumonitis. 5.Gastrointestinal Diseases: Regional enteritis and ulcerative colitis. 6.Hematologic Disorders: Acquired (autoimmune) hemolytic anemia, idiopathic thrombocytopenic purpura in adults, secondary thrombocytopenia in adults, congenital hypoplastic anemia.