Generic Name: Aceclofenac

Therapeutic Name: Analgesic & Antipyretic

  • Prescription:
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Zolonac tablet : Each film coated tablet contains Aceclofenac BP 100 mg.
Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic
properties. It is a potent inhibitor of the enzyme cyclooxygenase, which is involved in
the production of prostaglandin. After oral administration, Aceclofenac is rapidly and
completely absorbed as unchanged drug. Peak plasma concentrations are reached
approximately 1.25 to 3.00 hours following ingestion. Aceclofenac penetrates into the
synovial fluid, where the concentrations reach approximately 57% of those in plasma.
The mean plasma elimination half-life is around 4 hours. Aceclofenac is highly
protein-bound (>99%). Aceclofenac circulates mainly as unchanged drug, 4-Hydroxy
Aceclofenac is the main metabolite detected in plasma. Approximately two-thirds of
the administered dose is excreted via the urine, mainly as hydroxymetabolites.