COMPOSITION: Tygin tablet: Each lm-coated tablet contains Tiemonium Methylsulphate INN 50 mg. PHARMACOLOGY: Tiemonium Methylsulphate is a quaternary ammonium antimuscarinic agent with peripheral eect similar to those of atropine. Tiemonium Methylsulphate strengthens calcium bonding with phospholipids and proteins thus stabilizing the cell membrane of the Gl tract. INDICATIONS: Tygin (Tiemonium Methylsulphate) is an antispasmodic drug. It reduces muscle spasms of the intestine, biliary system, bladder and uterus. It is indicated for pain in gastrointestinal and biliary diseases and in urology and gynaecology such as gastroenteritis, diarrhoea, dysentery, biliary colic, enterocolitis, cholecystitis, colonopathies, mild cystitis and spasmodic dysmenorrhoea. It is also indicated for acute pain. DOSAGE AND ADMINISTRATION: Oral: The usual dose is 100 to 300 mg (2 to 6 tablets) per day in divided doses.