COMPOSITION :
Tenopin Tablet : Each tablet contains Amlodipine 5 mg as Amlodipine Besilate BP and
Atenolol BP 50 mg.
PHARMACOLOGY :
Tenopin is a fixed dose combination of Amlodipine and Atenolol. Amlodipine is a
dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions
into vascular smooth muscle and cardiac muscle; it has a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine reduces tone, decreases coronary
vasoreactivity, and lowers cardiac demand by reducing after load.
Atenolol is a cardioselective beta-blocker. It does not possess any membrane stabilizing
action. The cardio selectivity is dose related. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin level and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.