Generic Name: Mifepristone & Misoprostol

Therapeutic Name: Abortificient

  • Prescription:
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Each pack contains 2 blister strips. Mprix Strip: Single strip contains 1 tablet of
Mifepristone USP 200 mg. Misotec Strip: Single strip contains 4 tablets of Misoprostol
USP 200 mcg each.
MTP Kit contains 1 tablet of Mprix (Mifepristone) 200 mg to be given orally and 4
tablets of Misotec (Misoprostol) 200 mcg each to be given buccally for early Menstrual
Regulation (MR) or medical termination of pregnancy up to 9 weeks (63 days) of
Mprix: The anti-progestational activity of mifepristone results from competitive
interaction with progesterone at progesterone-receptor sites. Based on studies with
various oral doses in several animal species (mouse, rat, rabbit and monkey), the
compound inhibits the activity of endogenous or exogenous progesterone and the
termination of pregnancy results. During pregnancy, the compound sensitizes the
myometrium to the contraction-inducing activity of prostaglandins. Mifepristone also
exhibits antiglucocorticoid and weak antiandrogenic activity. Misotec: Prostaglandin E 1
causes myometrial contractions by interacting with specific receptors on myometrial cells.
This interaction results in a change in calcium concentration, thereby initiating muscle
contraction. By interacting with prostaglandin receptors, misoprostol causes the cervix to
soften and the uterus to contract, resulting in the expulsion of the uterine contents.