FLUKZOL

Generic Name: Fluconazole BP

Therapeutic Name: Antifungals & Topical Steroids

  • Prescription:
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COMPOSITION
Flukzol 50 Capsule: Each capsule contains Fluconazole BP 50 mg.
Flukzol 150 Capsule: Each capsule contains Fluconazole BP 150 mg.

PHARMACOLOGY
Fluconazole is a triazole antifungal drug which acts by inhibition of the
ergosterol component of the fungal cell membrane. It is active against a
broad spectrum of fungal pathogens.
Fluconazole is normally administered orally. Following oral administration,
absorption is rapid and extensive, with >90% of the dose being absorbed.
Bioavailability is the same in the fasting and fed states and Fluconazole is
unaffected by gastric pH. The plasma half life is approximately 30 h. The
plasma protein binding of Fluconazole is low, at 11% and the drug is widely
distributed throughout the body. Most of the dose of Fluconazole is excreted
unchanged in the urine , the remainder of the dose being eliminated in the
urine as metabolites.

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