COMPOSITION:
Dersole 0.05% cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg.
Dersole 0.05% ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg.
PHARMACOLOGY :
Clobetasol propionate is a highly potent topical steroid. lt has both local anti-inflammatory and
immunosuppressive activity. Clobetasol, as the propionate salt, is only used topically on the skin
and its effects are limited to the local anti-inflammatory activity. When given systemically it has
standard glucocorticoid activity and binds with high affinity to the glucocorticoid receptor.
Clobetasol propionate inhibits the adherence of neutrophils and monocyte-macrophages to the
capillary endothelial cells inflammed area. Clobetasol blocks the effect of macrophage migration
inhibitory factor and decreases the activation of plasminogen to plasmin.
INDICATIONS :
1. Initial control of all forms of hyperacute eczema in all age groups (in children for no longer
than a few days)
2. Chronic hyperkeratotic eczema of the hands and feet and patches of chronic lichen simplex
3. Chronic hyperkeratotic psoriasis of any area of the body
4. Severe acute photosensitivity
5. Hypertrophic lichen planus
6. Localized bullous disorders
7. Keloid scarring
8. Pretibial myxoedema
9. Vitiligo
10. Suppression of reaction after cryotherapy