COMPOSITION Coxsafe 60 Tablet: Each film coated tablet contains Etoricoxib INN 60 mg. Coxsafe 90 Tablet: Each film coated tablet contains Etoricoxib INN 90 mg. Coxsafe 120 Tablet: Each film coated tablet contains Etoricoxib INN 120 mg. PHARMACOLOGY Etoricoxib is a Nonsteroidal Anti-inflammatory Drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic activities. It is a potent, orally active, highly selective cyclooxygenase-2 (COX-2) inhibitor within and above the clinical dose range. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation and fever. Selective inhibition of COX-2 by Etoricoxib decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelets function. INDICATIONS Etoricoxib is indicated for relief of pain and inflammation in Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Acute Gout, Primary Dysmenorrhoea, Postoperative Dental Pain & other Chronic Musculoskeletal Disorders. DOSAGE AND ADMINISTRATION Adult and adolescent (over 16 years): Osteoarthritis & Chronic Musculoskeletal Disorders and Dysmenorrhoea: 60 mg once daily Rheumatoid Arthritis: 90 mg once daily Pain following Dental Surgery & Acute Gout: 120 mg once daily Safety and effectiveness of Etoricoxib in paediatric patients have not been established. Or as directed by physician.