COMPOSITION Ceclav 250 Tablet: Each film coated tablet contains 250 mg of Cefuroxime as Cefuroxime Axetil BP and 62.5 mg of Clavulanic Acid as Diluted Potassium Clavulanate BP. Ceclav 500 Tablet: Each film coated tablet contains 500 mg of Cefuroxime as Cefuroxime Axetil BP and 125 mg of Clavulanic Acid as Diluted Potassium Clavulanate BP. Ceclav Granules for Suspension: After reconstitution, each 5 ml suspension contains 125 mg of Cefuroxime as Cefuroxime Axetil BP and 31.25 mg of Clavulanic Acid as Diluted Potassium Clavulanate BP. PHARMACOLOGY Cefuroxime has bactericidal activity against a wide range of common pathogens, including beta-lactamase producing strains. The bactericidal action of Cefuroxime results from inhibition of cell wall synthesis by binding to essential target proteins. Cefuroxime has good stability to bacterial beta-lactamases. Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. It has poor intrinsic antimicrobial activity, but it is an irreversible binder of beta-lactamases produced by a wide range of gram positive and gram negative microorganism. INDICATIONS Pharyngitis/tonsillitis: Caused by Streptococcus pyogenes. Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Moraxella Catarrhalis (including beta-lactamase-producing strains) or Streptococcus pyogenes. Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae, or Haemophilus influenzae (non-beta lactamase producing strains only). Lower respiratory tract infections including pneumoniae: Caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase and non-penicillinase producing strains), Streptococcus pyogenes, Escherichia coli. Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis: Caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus parainfluenzae (beta-lactamase negative strains). Skin and Skin-structure infections: Caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, Escherichia coli, Klebsiella spp., and Enterobacter spp. Urinary tract infections: Caused by Escherichia coli or Klebsiella pneumoniae. Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains). Gonorrhoea: Uncomplicated and disseminated gonococcal infections due to Neisseria gonorrhoea (penicillinase- and non-penicillinase-producing strains) in both males and females. Early Lyme disease: (erythema migrans) caused by Borrelia burgdorferi. Septicemia: Caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae (including ampicillin-resistant strains), and Klebsiella spp. Meningitis: Caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis, and Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains). Surgical Prophylaxis: Prophylaxis against infections in abdominal, pelvic, orthopedic, cardiac, pulmonary, esophageal and vascular surgery where there is increased risk for infection.