Burnless

Generic Name: Silver Sulfadiazine USP

Therapeutic Name: Antibacterial Drugs

  • Prescription:
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Composition :
Burnless 1% Cream : Each gram cream contains Silver Sulfadiazine USP 10 mg.
Pharmacology :
Burnless cream contains Silver Sulfadiazine which is the silver salt of N-(Pyrimidin-2-yl) sulphanilamide.
It is a sulfonamide. It is used topically for the prevention and treatment of infections in severe burns. lt is
effective against Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa, yeast
and fungi. It has a bactericidal action; in contrast to sulfadiazine, the silver salt acts primarily on the cell
membrane and cell wall and its action is not antagonised by p-aminobenzoic acid. The compound is
painless upon application. It has a pleasant cooling effect to the burnt surface. lt is considered by most
authorities to be one of the agents of choice for the prevention of infection of burns.
Little silver is absorbed. Silver is released from the preparation in concentrations that are selectively
toxic to the microorganisms. Upto about 10% of the sulfadiazine may be absorbed. Concentrations in
blood of 10 to 20 mcg per ml have been reported although higher concentrations may be achieved
when extensive areas of the body are treated. Silver Sulfadiazine is slowly converted to sulfadiazine in
contact with wound exudates.
Indications :
Prophylaxis and treatment of infection in burn wounds
. As an adjunct to short-term treatment of infection in
a) Leg ulcers
b) Pressure sores
. As an adjunct to prophylaxis of infection in
a) Skin graft donor sites
b) Extensive abrasions
. Conservative management of finger-tip injuries