Cefixime is a broad spectrum cephalosporin antibiotic of third generation for oral administration. It is a bactericidal antibiotic and is stable to hydrolysis by many beta-lactamases. Cefixime kills bacteria by interfering in the synthesis of the bacterial cell wall. Cefixime is highly active against Neiaerio gonorrhoeoe, Hoemopbilus influenza?, Moraxdto catarrhalis including betalactamase producers, most of the Enterobacteriaceae, beta-haemolytic Streptococci (group A & B) and Streptococcus pneumoniae. Cefixime is more active than other oral cephalosporins against Escherichia coli, Ktebsielta spp,, Pioteus mirabilis, Serratio marcescens and Streptococcus pyogenes. 40-50% of an oral dose is absorbed from gastro-imestinal tract, whether taken with meals or not. The plasma half-life is usually about 3 to 4 hours and may be prolonged when there is renal impairment. About 65% is bound to plasma protein.Cefixime is mainly excreted unchanged in bile and urine.